Outputs

Dissemination Material



COMBAR Publications


  • Read also the COMBAR special issue in Parasite!
  • Anthelmintic properties of essential oils to control gastrointestinal nematodes in sheep - in vitro and in vivo studies. Štrbac F., Bosco A., Maurelli M.P., Ratajac R., Stojanović D., Simin N., Orčić D., Pušić I., Krnjajić S., Sotiraki S., Saralli G., Cringoli G., Rinaldi L. Veterinary Sciences 9(2), 93.https://doi.org/10.3390/vetsci9020093
  • Anthelmintic resistance in ruminants: challenges and solutions. Charlier J., Bartly D.J., Sotiraki S., Martinez-Valladares M., Claerebout E., von Samson-Himmelstjerna G., Thamsborg S.M., Hoste H., Morgan E.R., Rinaldi L., 2022. Advances in Parasitology 115, 171-227.https://doi.org/10.1016/bs.apar.2021.12.002
  • Use of agro industrial byproducts containing tannins for the integrated control of gastrointestinal nematodes in ruminants. Hoste H., Meza O Campos G., Marchand S., Sotiraki S., Saratsi K., Blomstrand B;M., Williams A.R., Thamsborg S.M., Athanasiadou S., Einemark H., Torres Acosta J.F.J, Mancilla Montelongo G., Sandoval Castro C., Costa Junior L. Louvandini H., Mesquila Souza D., Salminen JP, Karonen M., Engstrom M., Charlier J., Niderkorn V., Morgan E., 2022. Parasite 29, 10.https://doi.org/10.1051/parasite/2022010
  • Effect of Artemisia absinthium and Malva sylvestris on antioxidant parameters and abomasal histopathology in lambs experimentally infected with Haemonchus contortus. Mravčáková D., Sobczak-Filipiak M., Váradyová Z., Kucková K., Čobanová K., Maršík P., Tauchen J., Vadlejch J., Mickiewicz M., Kaba J., Várady M., 2021. Animals 11(2), 462https://doi.org/10.3390/ani11020462
  • Point of care colourimetric and lateral flow LAMP assay for the detection of Haemonchus contortus in ruminant faecal samples. Khangembam R., Tóth M., Vass N., Várady M., Czeglédi L., Farkas R., Antonopoulos A., 2021. Parasite 28, 82https://doi.org/10.1051/parasite/2021078
  • The identification and semi-quantitative assessment of gastrointestinal nematodes in faecal samples using multiplex real-time PCR assays.Reslova, N., Skorpikova, L., Kyrianova, I.A., Vadlejch, J., Höglund, J., Skuce, P., Kasny, M., 2021. Parasites & Vectors 14, 391.https://doi.org/10.1186/s13071-021-04882-4
  • Multispecific resistance of sheep trichostrongylids in Austria.Untersweg F., Ferner V., Wiedermann S., Göller M., Hörl-Rannegger M., Kaiser W., Joachim A., Rinaldi L., Krücken J., Hinney B., 2021. Parasite 28, 50https://doi.org/10.1051/parasite/2021048
  • Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus?Babják M., Königová A., Dolinská M.U., Kupčinskas T., Vadlejch J., von Samson-Himmelstjerna G., Petkevičius S., Várady M., 2021. Parasite 28, 62.https://doi.org/10.1051/parasite/2021059
  • Treatment against helminths in Norwegian sheep: a questionnaire-based survey.Gravdal M., Robertson L.J., Tysnes K.R., Höglund J., Chartier C., Stuen S., 2021. Parasite 28, 63https://doi.org/10.1051/parasite/2021061
  • In vitro anthelmintic activity of an aqueous extract of Glycyrrhiza glabra and of glycyrrhetinic acid against gastrointestinal nematodes of small ruminants.Maestrini M., Molento M.B., Forzan M., Perrucci S., 2021. Parasite 28, 64.https://doi.org/10.1051/parasite/2021060
  • First Report of Anthelmintic Resistance in Gastrointestinal Nematodes in Goats in Romania.Potârniche A.V., Mickiewicz M., Olah D., Cerbu C., Spînu M., Hari A., Györke A., Moroz A., Czopowicz M., Várady M., Kaba J., 2021. Animals 11(10), 2761.https://doi.org/10.3390/ani11102761
  • Constraints of using historical data for modelling the spatial distribution of helminth parasites in ruminants.Hendrickx A., Marsboom C., Rinaldi L., Rose Vineer H., Morgoglione M.E., Sotariki S., Cringoli G., Claerebout E., Hendrickx G., 2021. Parasite 28, 46.https://doi.org/10.1051/parasite/2021042
  • Resistance of strongylid nematodes to anthelmintic drugs and driving factors at Czech goat farms.Vadlejch J., Kyriánová I.A., Várady M., Charlier J., 2021. BMC Vet Res 17, 106.
    https://doi.org/10.1186/s12917-021-02819-8
  • Prevalence of anthelmintic resistance of gastrointestinal nematodes in Polish goat herds assessed by the larval development test.Mickiewicz M., Czopowicz M., Moroz A., Potărniche A.V., Szaluś-Jordanow O., Spinu M., Górski P., Markowska-Daniel I., Várady M., Kaba J., 2021. BMC Veterinary Research 17, 19.
    https://doi.org/10.1186/s12917-020-02721-9
  • Increasing importance of anthelmintic resistance in European livestock: creation and meta-analysis of an open database.Rose Vineer H., Morgan E.R., Hertzberg H., Bartley D.J., Bosco A., Charlier J., Chartier C., Claerebout E., de Waal T., Hendrickx G., Hinney B., Höglund J., Ježek J., Kašný M., Keane O.M., Martínez-Valladares M., Mateus T.L., McIntyre J., Mickiewicz M., Munoz A.M., Phythian C.J., Ploeger H.W., Vergles Rataj A., Skuce P.J., Simin S., Sotiraki S., Spinu M., Stuen S., Thamsborg S.M., Vadlejch J., Varady M., von Samson-Himmelstjerna G., Rinaldi L., 2020. Parasite, 27 (2020) 69
    https://doi.org/10.1051/parasite/2020062
  • A qualitative market analysis applied to Mini-FLOTAC for diagnosis of helminth infections in ruminants.Maurelli M.P., Dourado Martins O.M., Morgan E.R., Charlier J., Cringoli G., Mateus T.L., Bacescu B., Chartier C., Claerebout E., de Waal T., Helm C., Hertzberg H., Hinney B., Höglund J., Kyriánová I.A., Mickiewicz, M., Petkevičius S., Simin S., Sotiraki S., Tosheska M., Toth M., Martínez-Valladares, Varady M., Sekovska B., von Samson-Himmelstjerna G., Rinaldi L., 2020. Frontiers in Veterinary Science 7, 580649.
    https://doi.org/10.3389/fvets.2020.580649
  • The threat of reduced efficacy of anthelmintics against gastrointestinal nematodes in sheep from an area considered anthelmintic resistance-free.Bosco A., Kiessler J., Amadesi A., Varady M., Hinney B., Ianiello D., Maurelli M.P., Cringoli G., Rinaldi L., 2020. Parasites Vectors 13: 457.
    https://doi.org/10.1186/s13071-020-04329-2
  • Assessment of the F200Y mutation frequency in the β tubulin gene of Haemonchus contortus following the exposure to a discriminating concentration of thiabendazole in the egg hatch test.Baltrušis P., Komáromyová M., Várady M., von Samson-Himmelstjerna G., Höglund J., 2020. Exp Parasitol 217, 107957.
    https://www.sciencedirect.com/science/article/pii/S0014489420302411?via%3Dihub
  • Feeding of carob (Ceratonia siliqua) to sheep infected with gastrointestinal nematodes reduces faecal egg counts and worm fecundity.Saratsi K., Hoste H., Voutzourakis N., Tzanidakis N., Stefanakis A, Thamsborg S.M., Mueller-Harvey I., Hadjigeorgiou I., Sotiraki S., 2020. Vet Parasitol 284, 109200.
    https://www.sciencedirect.com/science/article/pii/S0304401720301801?dgcid=coauthor
  • The first report of multidrug resistance in gastrointestinal nematodes in goat population in Poland.Mickiewicz M., Czopowicz M., Kawecka-Grochocka E., Moroz A., Szalus-Jordanow O., Varady M., Königova A., Spinu M., Gorski P., Bagnicka E., Kaba J., 2020. BMC Vet Res 16: 270.
    https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-020-02501-5
  • Initial assessment of the economic burden of major parasitic helminth infections to the ruminant livestock industry in Europe.Charlier J., Rinaldi L., Musella V., Ploeger, H.W., Chartier, C., Rose Vineer H., Hinney B., von Samson-Himmelstjerna G., Băcescu B., Mickiewicz M., Mateus L., Martinez-Valladares M., Quealy S., Azaizeh H., Sekovska B., Akkari H., Petkevicius S., Hektoen L., Höglund J., Morgan E.R., Bartley D.J., Claerebout E., 2020. Prev Vet Med, 105103.
    https://doi.org/10.1016/j.prevetmed.2020.105103
  • Cattle gastrointestinal nematode egg‑spiked faecal samples: high recovery rates using the Mini‑FLOTAC technique. Amadesi A., Bosco A., Rinaldi L., Cringoli G., Claerebout E., Maurelli M.P., 2020. Parasites Vectors 13:230.
    https://doi.org/10.1186/s13071-020-04107-0
  • High frequency of benzimidazole resistance alleles in trichostrongyloids from Austrian sheep flocks in an alpine transhumance management system. Hinney B., Schoiswohl J., Melville L., Ameen V.J., Wille-Piazzai W., Bauer K., Joachim A., Krücken J., Skuce P.J., Krametter-Frötscher R., 2020. BMC Vet Res16:132
    https://doi.org/10.1186/s12917-020-02353-z
  • Assessment of anthelmintic efficacy against cattle gastrointestinal nematodes in western France and southern Italy. Chartier C., Ravinet N., Bosco A., Dufourd E., Gadanho M., Chauvin A., Charlier J., Maurelli M.P., Cringoli G., Rinaldi L., 2020. J Helminthol 94, e125, 1-3.
    https://doi.org/10.1017/S0022149X20000085
  • GLOWORM-PARA: a flexible framework to simulate the population dynamics of the parasitic phase of gastrointestinal nematodes infecting grazing livestock. Rose Vineer H., Verschave S.H., Claerebout E., Vercruysse J., Shaw D.J., Charlier J., Morgan E.R., 2020. Int J Parasitol, in press
    https://doi.org/10.1016/j.ijpara.2019.11.005
  • Biology and epidemiology of gastrointestinal nematodes in cattle. Charlier J., Höglund J., Morgan E.R., Geldhof P., Vercruysse J., Claerebout E., 2020. Vet Clin North Am Food Anim Pract 36, 1-15
    https://doi.org/10.1016/j.cvfa.2019.11.001
  • Hydro-Ethanolic extract of Mentha pulegium exhibit anthelmintic and antioxidant proprieties in vitro and in vivo. Sebai E., Serairi R., Saratsi K., Abidi A., Sendi N., Darghouth M.A., Wilson M.S., Sotiraki S., Akkari H., 2020. Acta Parasitologica
    https://doi.org/10.2478/s11686-020-00169-3
  • Rapid assessment of faecal egg count and faecal egg count reduction through composite sampling in cattle. Rinaldi L, Amadesi A, Dufourd E, Bosco A, Gadanho M, Lehebel A, Maurelli MP, Chauvin A, Charlier J, Cringoli G, Ravinet N, Chartier C., 2019. Parasites & Vectors 12, 353.
    https://parasitesandvectors.biomedcentral.com/articles/10.1186/s13071-019-3601-x
  • Benefits of condensed tannins in forage legumes fed to ruminants: importance of structure, concentration and diet composition MUELLER-HARVEY, I.; BEE, G., DOHME-MEIER, F., HOSTE, H.,KARONEN M., KOELLIKER, R., LÜSCHER, A., NIDERKORN, V.,PELLIKAAN, W., SALMINEN, JP., SKOT, LEIF., SMITH, L., THAMSBORG, S., TOTTERDELL, P., WILKINSON, I., WILLIAMS, A., AZUHNWI , B., BAERT, N., GROSSE BRINKHAUS, A., COPANI, G., DESRUES, O., DRAKE, C., ENGSTRÖM, M., FRYGANAS, C., GIRARD, M. Crop Sciences 58, 1-25. 2019
    https://dl.sciencesocieties.org/publications/cs/abstracts/0/0/cropsci2017.06.0369
  • 100 questions in livestock helminthology research. Morgan E.R., Aziz N.A., Blanchard A., Charlier J., Charvet C., Claerebout E., Geldhof P., Greer A.W., Hertzberg H., Hodgkinson J., Höglund J., Hoste H., Kaplan R.M., Martínez-Valladares M., Mitchell S., Ploeger H.W., Rinaldi L., von Samson-Himmelstjerna G., Sotiraki S., Schnyder M., Skuce P., Bartley D., Kenyon F., Thamsborg S.M., Rose Vineer H., de Waal T., Williams A.R., van Wyk J.A., Vercruysse J., 2018. Trends Parasitol 35, 52-71. 2018
    https://www.cell.com/trends/parasitology/fulltext/S1471-4922(18)30237-X
  • Mind the gaps in research on the control of gastrointestinal nematodes of farmed ruminants and pigs. Charlier J., Thamsborg S.M., Bartley D.J., Skuce P.J., Geurden T., Hoste H., Williams A.R., Sotiraki S., Höglund J., Chartier C., Geldhof P., van Dijk J., Rinaldi L., Morgan E.R., von Samson-Himmelstjerna G., Vercruysse J., Claerebout E. Transboundary and Emerging Diseases 65(Suppl.1), 217-234. 2018
    https://onlinelibrary.wiley.com/doi/full/10.1111/tbed.12707
  • Control of helminth ruminant infections by 2030. Vercruysse J., Charlier J., Van Dijk J., Morgan E.R., Geary T., von Samson-Himmelstjerna G., Claerebout E, 2018. Parasitology, 1-10. 2018
    https://www.cambridge.org/core/journals/parasitology/article/control-of-helminth-ruminant-infections-by-2030/5E2B8A7B2CFF4E9A7AEA35E33FC7AD9A


Other relevant publications

  • Genetic variants in dyf-7 validated by droplet digital PCR are not drivers for ivermectin resistance in Haemonchus contortus. Elmahalawy S. T, Halvarsson P., Skarin M., Höglund J., 2018. International Journal for Parasitology: Drugs and Drug Resistance 8, 278-286. 2018
    https://doi.org/10.1016/j.ijpddr.2018.04.005
  • Des plantes contenant des tannins condensés : un modèle d’alicament pour gérer les vers parasites en élevages des petits ruminants. Hoste H., Torres Acosta F., Sotiraki S., Houzangbe AdoteS., Kabore A., Costa Junior L., Louvandini H., Gaudin E., Mueller Harvey I., 2018. Innovations Agronomiques 68, 19-29. 2018
    https://www6.inra.fr/ciag/content/download/6434/47664/file/Vol66-3-Hoste%20et%20al.pdf
  • Hidden in plain sight- multiple resistant species within a strongyle community. McIntyre J., Hamer K., Morrison A.A., Bartley D.J., Sargison N., Devaney E, Laing R., 2018. Veterinary Parasitology, 258, 79-87. 2018
    https://doi:10.1016/j.vetpar.2018.06.012
  • A genome resequencing-based genetic map reveals the recombination landscape of an outbred parasitic nematode in the presence of polyploidy and polyandry. Doyle S.R., Laing R., Bartley D.J., Britton C., Chaudhry U., Gilleard J.S., Holroyd N., Mable B.K., Maitland K., Morrison A.A., Tait A., Tracey A., Berriman M., Devaney E., Cotton J.A., Sargison N.D., 2018. Genome Biology and Evolution, 10(2):396-409. 2018
    https://doi:10.1093/gbe/evx269
  • Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus. Doyle S.R., Illingworth C.J.R., Laing R., Bartley D.J., Redman E, Martinelli A. Holroyd N., Morrison A.A., Rezansoff A., Tracey A., Devaney E., Berriman M., Sargison N.D., Cotton J.A., Gilleard J.S., 2019. BMC Genomics 20, 218. 2018
    https://doi:10.1186/s12864-019-5592-6



Press Releases

12/02/2018: Announcement of the network

9/10/2018: Scientists discuss research towards mitigating anthelmintic resistance in livestock

6/9/2019: Report COMBAR mid-term meeting Ghent

29/07/2020: Drug resistant parasites cost European livestock industry millions each year

17/05/2021: Test Don’t Guess: A fun way to learn about parasite monitoring to improve livestock performance!

16/06/2021: A series of webinars on Anthelmintic Resistance in Ruminants: Challenges and Solutions



Research projects

Acronym Title Duration Countries involved Funder Weblink
BUGS Building upon the Genome https://bugconsortium.wordpress.com/
ENWIR Extreme weather, nematode infection in ruminants and farmers’ responses 1/1/2019-31/12/2022 Sweden FORMAS https://www.slu.se/en/departments/biomedical-sciences-veterinary-public-health/research/parasitology/
LIFLUMILK The common liver fluke in dairy cattle – its infection dynamics and impact on the milk production 1/1/2017-31/12/2020 Sweden FORMAS https://www.slu.se/en/departments/biomedical-sciences-veterinary-public-health/research/parasitology/
MTGIN Molecular tools for detection of gastrointestinal parasites and anthelmintic resistance in sheep 1/1/2017-31/12/2020 Sweden Swedish Foundation for Agricultural Reserach (SLF) https://www.slu.se/en/departments/biomedical-sciences-veterinary-public-health/research/parasitology/
PARAGONE Vaccines for animal parasites 1/3/2015-31/3/2019 UK, Ireland, Spain, Norway, Germany, Belgium, Uruguay EU H2020 https://www.paragoneh2020.eu/
PDMAFAM Parasitic diseases and markers for the assessment of animal welfare with applications in grazing livestock 1/1/2017-31/12/2020 Sweden FORMAS https://www.slu.se/en/departments/biomedical-sciences-veterinary-public-health/research/parasitology/
PIOSF Parasite intervention in organic sheep flocks 1/1/2017-31/12/2020 Sweden SLU-Ekoforsk https://www.slu.se/en/departments/biomedical-sciences-veterinary-public-health/research/parasitology/
Proteolysis in eggs of parasitic worms (Schistosoma mansoni and Fasciola hepatica): role in pathology and its regulation 1/01/2019-31/12/2021 1 Grant Agency of Czech Republic https://sites.google.com/view/fasciola-hepatica
MERINOparasite Identification of genetic markers underlying genetic resistance to internal parasites in the Merina Branca sheep breed using the OvineHD Beadchip array 01/10/2018 – 01/10/2021 Portugal FCT https://projects.iniav.pt/merinoparasite/en/
Multivariable biostatistical model based on in vitro methods for prediction of anthelmintic resistance in goats 01/01/2021 - 31/12/2023 Poland Poland National Science Center
INTER-EXCELLENCE / INTER-COST: Pilot strategic plan of combating against the resistant strains of parasitic worms in the populations of Czech farm ruminants 01/06/2019 - 01/08/2021 Czech Republic Ministry of Education, Youth and Sports https://sites.google.com/mail.muni.cz/anthelmintickarezistence/dom%C5%AF?authuser=0
INVRUM Spread of invasive parasite species and their devastating effects on the biodiversity of native ruminant species 01/02/2022-31/12/2024 Czech Republic Technology Agency of the Czech Republic
ALTREAT Alternative parasite control of small ruminant 1/7/2019 – 30/6/2023 Slovakia Slovak research and development agency of Ministry of education, science, research and sport of the Slovak Republic https://www.apvv.sk/?lang=en
Anthelmintic resistance of parasites – challenges, perspectives and solutions 1/7/2015 – 28/6/2019 Slovakia Slovak research and development agency of Ministry of education, science, research and sport of the Slovak Republic https://www.apvv.sk/?lang=en
Diagnostic challenges and forgotten parasites of domestic ruminants 1/1/2019 – 31/12/2021 Slovakia Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic and Slovak Academy of Sciences https://www.minedu.sk/vedecka-grantova-agentura-msvvas-sr-a-sav-vega/
Ivermectin – antiparasitic therapy in small ruminants, resistance and food residues 1/1/2022 – 31/12/2025 Slovakia Scientific Grant Agency of the Ministry of Education, Science, Research and Sport of the Slovak Republic and Slovak Academy of Sciences https://www.minedu.sk/vedecka-grantova-agentura-msvvas-sr-a-sav-vega/
ParaGÖAT Parasites of grazing goats in Austria: Monitoring drug resistance and development of sustainable control strategies for the practice (ParaGÖAT) 2/5/2022- 30/4/2024 Austria DaFNE (BMLRT)
Parasites of cattle in Tyrol: monitoring of anthelmintic resistance (Fasciola) and development of predictive models 1/7/2022- 30/6/2026 Austria own sources or DaFNE
Parasites of cattle in the alpine region, dynamics of infection and nemabiome analysis 1/2/2021-30/5/2022 Austria own sources and Boehringer Ingelheim
Anthelmintic resistance in sheep and development of a digital PCR for resistance allele detection 1/8/2018- 30/6/2022 Austria own sources
Parasites in Capricorns 1/6/2021-30/5/2022 Austria own sources
Tricoscreening Control of ovine tricostrongilidosis: design, synthesis and clinical trials of the efficacy of new molecules with antihelminthic action. Subproject 1: evaluation of the deworming activity of new molecules through in vitro and in vivo tests against tricostrongilides. Jan. 2017- Dec. 2020 Spain Ministry of Economy and Competitiveness
Evaluation of deworming activity of new molecules by in vitro testing against tricostrongilides. 26/07/2017 -31/10/2019 Spain Junta de Castilla y León
NEMATOOLS New tools for drug discovery and detection of anthelmintic resistance against gastrointestinal nematodes in small ruminants. 09/2021-08/2024 Spain Ministry of Science and Innovation
Integrated management of gastrointestinal nematode infections in lambs under temperate climate conditions: Combined efficacy of a mono-species (Haemonchus-vaccine) and a broad spectrum (mixed species grazing management) control strategy 1/1/2020 – 31/12/2021 Switzerland Federal Food Safety and Veterinary Office FSVO